Lucas B. Sullivan

Reductive carboxylation supports growth in tumour cells with defective mitochondria

Andrew R. Mullen, William W. Wheaton, Eunsook S. Jin et al. · Nature · 2011 · 1.3K citations · Full text

Biochemistry, Mitochondrial Function, Organelle Dynamic +7

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

Lucas B. Sullivan, Dan Y. Gui, Aaron M. Hosios et al. · Cell · 2015 · 1.1K citations · Full text

Cell Physiology, Reductive Stress, Essential Function +13

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

William W. Wheaton, Samuel E. Weinberg, Robert B. Hamanaka et al. · eLife · 2014 · 1.1K citations · Full text

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

Shawn M. Davidson, Thales Papagiannakopoulos, Benjamin A. Olenchock et al. · Cell Metabolism · 2016 · 740 citations · Full text

Oncology, Tumor Microenvironment, Oncogenic Agent +13

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan et al. · Nature Chemical Biology · 2016 · 571 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Serine Synthesis +10