Tam Tran

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

Mary E. Matyskiela, Gang Lu, Takumi Ito et al. · Nature · 2016 · 670 citations

Life Sciences, Biochemistry, Molecular Biology +11

CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth <i>in vitro</i>

Toshiya Tsuji, Lisa M. Sapinoso, Tam Tran et al. · Oncotarget · 2017 · 63 citations · Full text

Life Sciences, Molecular Biology, Oncology +15

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

Jennifer R. Riggs, Mark A. Nagy, Jan Elsner et al. · Journal of Medicinal Chemistry · 2017 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +13

CC-223, a Potent and Selective Inhibitor of mTOR Kinase: <i>In Vitro</i> and <i>In Vivo</i> Characterization

Deborah S. Mortensen, Kimberly E. Fultz, Shuichan Xu et al. · Molecular Cancer Therapeutics · 2015 · 53 citations · Full text

Medicine, Oncology, Pharmacology +14

Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1–S Checkpoint

Dan Zhu, Shuichan Xu, Gordafaried Deyanat‐Yazdi et al. · Molecular Cancer Therapeutics · 2018 · 36 citations

Life Sciences, Oncology, Pharmacology +17