P. Hornyak

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia

Nícolas C. Hoch, Hana Hanzlíková, Stuart L. Rulten et al. · Nature · 2016 · 263 citations · Full text

Xrcc1 Mutation, Molecular Neuroscience, Genetic Disorder +6

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

Claire Breslin, P. Hornyak, Andrew J. Ridley et al. · Nucleic Acids Research · 2015 · 101 citations · Full text

Chromatin, Genome Instability, Xrcc1 Recruitment +15

Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

Luis Mariano Polo, Yingqi Xu, P. Hornyak et al. · Cell Reports · 2019 · 79 citations · Full text

Chromatin, Genome Instability, Transcriptional Regulation +14

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

T. Karlberg, P. Hornyak, A.F. Pinto et al. · Nature Communications · 2018 · 51 citations · Full text

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

P. Hornyak, Trevor Askwith, Sarah Walker et al. · Biochemical Journal · 2016 · 36 citations · Full text

Medicinal Chemistry, Tdp2 Enzyme Activity, Drug Target +15