Jeffrey Tom

A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease

Yevgeny Zolotarevsky, Gail Hecht, Athanasia Koutsouris et al. · Gastroenterology · 2002 · 379 citations · Full text

Membrane-permeant Peptide, Signal Transduction, Mlc Kinase +9

A Designed Peptide Ligase for Total Synthesis of Ribonuclease A with Unnatural Catalytic Residues

David Y. Jackson, John P. Burnier, Clifford Quan et al. · Science · 1994 · 284 citations

Bioorganic Chemistry, Engineering, Engineered Variant +18

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

Ingrid E. Wertz, Kim Newton, Dhaya Seshasayee et al. · Nature · 2015 · 251 citations

Inflammation, Anti-inflammatory, Autoimmune Disease +7

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

John A. Flygare, Maureen H. Beresini, Nageshwar Budha et al. · Journal of Medicinal Chemistry · 2012 · 247 citations · Full text

Apoptosis, Cell Death, Clinical Candidate +20

Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution

Lars Abrahmsén, Jeffrey Tom, John P. Burnier et al. · Biochemistry · 1991 · 247 citations

Engineering, Protein Assembly, Peptide Engineering +20