SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

Michelle Pacholec, John E. Bleasdale, Boris A. Chrunyk, +14

Journal of Biological Chemistry

Molecular BiologyCompounds Srt2183Molecular ResearchInsulin SignalingOxidative Stress +14

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice

Emily Cokorinos, Jake Delmore, Allan R. Reyes, +27

Cell Metabolism

Metabolic SyndromeMuscle PhysiologyMuscle FunctionMolecular PhysiologyHealth Sciences +13

Efficacy of telemedicine on glycaemic control in patients with type 2 diabetes: A meta-analysis

Julia De Groot, Dongjun Wu, Declan Flynn, +3

World Journal of Diabetes

Discovery of a Series of Imidazo[4,5-<i>b</i>]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ

Agustin Casimiro‐Garcia, Gary F. Filzen, Declan Flynn, +14

Journal of Medicinal Chemistry

Identification of Tetrahydropyrido[4,3-<i>d</i>]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

David W. Piotrowski, Kentaro Futatsugi, Joseph S. Warmus, +23

ACS Medicinal Chemistry Letters

Pharmaceutical ScienceImmunologyPharmacotherapyChemical BiologyAcceptable Potency +15

Optimization of triazole-based TGR5 agonists towards orally available agents

Kentaro Futatsugi, Kevin B. Bahnck, Martin Brenner, +28

MedChemComm

Medicinal ChemistryPharmaceutical ScienceScreening StrategyPreclinical Drug EvaluationMedicine +10

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

Agustin Casimiro‐Garcia, Ronald J. Heemstra, Christopher F. Bigge, +10

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineDual ActivityPharmacological AgentPharmacotherapy +5

Behavioral effects and receptor binding affinities of fentanyl derivatives in rhesus monkeys.

Charles P. France, Lisa R. Gerak, Declan Flynn, +5

Journal of Pharmacology and Experimental Therapeutics

Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™

Jean G. Sathish, Siddhartha Bhatt, Jamie K. DaSilva, +15

International Journal of Toxicology

Safety PharmacologyViral DiagnosticsPharmacologyAntiviral Drug DevelopmentTherapeutic Efficacy +9

Statistical power analysis of cardiovascular safety pharmacology studies in conscious rats

Siddhartha Bhatt, Dingzhou Li, Declan Flynn, +3

Journal of Pharmacological and Toxicological Methods

HypertensionHeart FailureStatistical Power AnalysisCardiovascular DiseaseMedicine +9