The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

Yun‐Hee Youm, Kim Nguyen, Ryan W. Grant, +14

Nature Medicine

InflammationMedicineImmunologyInflammation BiologyChronic Inflammation +4

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

Christina D. Camell, Jil Sander, Olga Spadaro, +10

Nature

InflammationAutophagyImmunologyCell DeathChronic Inflammation +4

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

Emily L. Goldberg, Jennifer L. Asher, Ryan D. Molony, +7

Cell Reports

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

Christina D. Camell, Patrick Günther, Aileen Lee, +9

Cell Metabolism

AgingAnti-agingBiogerontologyInflammationMetabolic Syndrome +14

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue

Emily L. Goldberg, Irina Shchukina, Jennifer L. Asher, +3

Nature Metabolism

ObesityMetabolic SyndromeVisceral Adipose TissueSignal TransductionPhysiology +12

Ketogenic diet activates protective γδ T cell responses against influenza virus infection

Emily L. Goldberg, Ryan D. Molony, Eriko Kudo, +4

Science Immunology

Adaptive Immune SystemImmunologyImmune RegulationImmunodominanceImmunologic Mechanism +17

Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis

Xinbo Zhang, Jeffrey G. McDonald, Binod Aryal, +15

Proceedings of the National Academy of Sciences

Lifespan‐extending caloric restriction or m <scp>TOR</scp> inhibition impair adaptive immunity of old mice by distinct mechanisms

Emily L. Goldberg, Melissa J. Romero‐Aleshire, Kristin R. Renkema, +8

Aging Cell

Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence

Olga Spadaro, Emily L. Goldberg, Christina D. Camell, +6

Cell Reports

IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2

Emily L. Goldberg, Irina Shchukina, Yun‐Hee Youm, +7

Cell Metabolism

InflammationMetabolic SyndromeObesityLifespan ExtensionAging +9