Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

Christina D. Camell, Jil Sander, Olga Spadaro, +10

Nature

InflammationAutophagyImmunologyCell DeathChronic Inflammation +4

Caloric restriction in humans reveals immunometabolic regulators of health span

Olga Spadaro, Yun‐Hee Youm, Irina Shchukina, +11

Science

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

Christina D. Camell, Patrick Günther, Aileen Lee, +9

Cell Metabolism

AgingAnti-agingBiogerontologyInflammationMetabolic Syndrome +14

IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge

Olga Spadaro, Christina D. Camell, Lidia Bosurgi, +4

Cell Reports

IL-27 signalling promotes adipocyte thermogenesis and energy expenditure

Qian Wang, Dehai Li, Guangchao Cao, +32

Nature

ObesityEnergy HomeostasisMedicinePhysiologyMetabolic Regulation +4

Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence

Olga Spadaro, Emily L. Goldberg, Christina D. Camell, +6

Cell Reports

Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms

Giuseppe Ferrandino, Rachel R. Kaspari, Olga Spadaro, +7

Proceedings of the National Academy of Sciences

Extrahepatic MechanismsImmunologyFatty Liver DiseaseInsulin SignalingAdipose Tissue Lipolysis +18

Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity

Seungjin Ryu, Olga Spadaro, Sviatoslav Sidorov, +9

Journal of Clinical Investigation

Metabolic DisorderImmunologyPathologyCell DeathMetabolic Remodeling +24