Alexander G. Sorets

Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

Hyosung Kim, Kun Leng, Jinhee Park et al. · Nature Communications · 2022 · 183 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

A microengineered Brain-Chip to model neuroinflammation in humans

Iosif Pediaditakis, Konstantia Kodella, Dimitris V. Manatakis et al. · iScience · 2022 · 88 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice

Sam Hana, Michael Peterson, Helen McLaughlin et al. · Gene Therapy · 2021 · 45 citations · Full text

Life Sciences, Genetics, Neuroscience +17

Caveolae-mediated transport at the injured blood–brain barrier as an underexplored pathway for central nervous system drug delivery

Alexander G. Sorets, Jonah C. Rosch, Craig L. Duvall et al. · Current Opinion in Chemical Engineering · 2020 · 29 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing

Shrusti S. Patel, Ella N. Hoogenboezem, Fang Yu et al. · Biomaterials · 2023 · 22 citations · Full text

Pharmacy, Molecular Pharmaceutics, Oncology +17