Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

Iosif Pediaditakis, Konstantia Kodella, Dimitris V. Manatakis, +8

Nature Communications

Neurosteroid Dehydroepiandrosterone Interacts with Nerve Growth Factor (NGF) Receptors, Preventing Neuronal Apoptosis

Iakovos Lazaridis, Ioannis Charalampopoulos, Vasileia Ismini Alexaki, +6

PLoS Biology

A microengineered Brain-Chip to model neuroinflammation in humans

Iosif Pediaditakis, Konstantia Kodella, Dimitris V. Manatakis, +8

iScience

Genetic Dissection of Neurotrophin Signaling through the p75 Neurotrophin Receptor

Ioannis Charalampopoulos, Annalisa Vicario, Iosif Pediaditakis, +3

Cell Reports

GeneticsApoptosisImmune RegulationImmunologyMolecular Biology +25

APRIL Binding to BCMA Activates a JNK2–FOXO3–GADD45 Pathway and Induces a G2/M Cell Growth Arrest in Liver Cells

George Notas, Vasileia Ismini Alexaki, Marilena Kampa, +9

The Journal of Immunology

ApoptosisImmunologyImmune RegulationCell DeathPathology +22

Differential Effects of Dehydroepiandrosterone and Testosterone in Prostate and Colon Cancer Cell Apoptosis: The Role of Nerve Growth Factor (NGF) Receptors

Vasileia Anagnostopoulou, Iosif Pediaditakis, Saad Alkahtani, +6

Endocrinology

Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer

Konstantina Kalyvianaki, V.M. Gebhart, Nikolaos Peroulis, +9

Scientific Reports

Dehydroepiandrosterone: An Ancestral Ligand of Neurotrophin Receptors

Iosif Pediaditakis, Ioannis Iliopoulos, Ioannis Theologidis, +4

Endocrinology

Molecular PhysiologyTyrosine ResiduesMedicinePhysiologyHormonal Receptor +12

Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation

Iosif Pediaditakis, Paschalis Efstathopoulos, Kyriakos C. Prousis, +13

Neuropharmacology

Medicinal ChemistryFunctional SelectivityTrka ReceptorsMedicinePhysiology +9

BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis

Iosif Pediaditakis, Alexandra Kourgiantaki, Kyriakos C. Prousis, +6

Frontiers in Pharmacology