Shrusti S. Patel

Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy

Ella N. Hoogenboezem, Shrusti S. Patel, Justin H. Lo et al. · Nature Communications · 2024 · 44 citations · Full text

Medicine, Molecular Biology, Oncology +15

Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes

Meredith A. Jackson, Sean K. Bedingfield, Fang Yu et al. · Biomaterials · 2018 · 35 citations · Full text

Pharmacy, Chemical Engineering, Molecular Pharmaceutics +16

Nonviral <i>In Vivo</i> Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles

R. Brock Fletcher, Larry D. Stokes, Isom B. Kelly et al. · ACS Nano · 2023 · 30 citations · Full text

Pharmacy, Bioengineering, Biotechnology +17

Intraductal Adaptation of the 4T1 Mouse Model of Breast Cancer Reveals Effects of the Epithelial Microenvironment on Tumor Progression and Metastasis

Huda I. Atiya, Anna Dvorkin‐Gheva, John A. Hassell et al. · Anticancer Research · 2019 · 29 citations · Full text

Medicine, Cancer Biology, Oncology +17

Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing

Shrusti S. Patel, Ella N. Hoogenboezem, Fang Yu et al. · Biomaterials · 2023 · 22 citations · Full text

Pharmacy, Molecular Pharmaceutics, Oncology +17