James Shorter

TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

Brian S. Johnson, David Snead, Jonathan J. Lee et al. · Journal of Biological Chemistry · 2009 · 787 citations · Full text

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Increase Toxicity +10

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

Jacob R. Mann, Amanda M. Gleixner, Jocelyn C. Mauna et al. · Neuron · 2019 · 547 citations · Full text

Signal Transduction, Molecular Neuroscience, Rna Binding Proteins +6

The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

Aaron D. Gitler, Brooke J. Bevis, James Shorter et al. · Proceedings of the National Academy of Sciences · 2007 · 537 citations · Full text

Alpha-syn Pathobiology, Alpha-syn Toxicity, Synaptic Signaling +16

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

X. Rosa, Mercedes Prudencio, Yuka Koike et al. · Nature · 2022 · 520 citations · Full text

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

F. Gasset-Rosa, Shan Lu, Haiyang Yu et al. · Neuron · 2019 · 499 citations · Full text

Nuclear Import, Cell Regulation, Medicine +9