James Shorter

TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

Brian S. Johnson, David Snead, Jonathan J. Lee et al. · Journal of Biological Chemistry · 2009 · 804 citations · Full text

Life Sciences, Neurology, Neuroscience +17

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

X. Rosa, Mercedes Prudencio, Yuka Koike et al. · Nature · 2022 · 575 citations · Full text

Life Sciences, Genetics, Neuroscience +17

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

Jacob R. Mann, Amanda M. Gleixner, Jocelyn C. Mauna et al. · Neuron · 2019 · 569 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +10

The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

Aaron D. Gitler, Brooke J. Bevis, James Shorter et al. · Proceedings of the National Academy of Sciences · 2007 · 542 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

F. Gasset-Rosa, Shan Lu, Haiyang Yu et al. · Neuron · 2019 · 526 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15