TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

Brian S. Johnson, David Snead, Jonathan J. Lee, +3

Journal of Biological Chemistry

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisIncrease ToxicityTdp-43 AggregatesDegenerative Disease +8

Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

Colin K. Deniston, John Salogiannis, Sebastian Mathea, +11

Nature

Signal TransductionMicrotubule InteractionCytoskeletonMolecular NeurobiologyMedicine +3

Synaptic Vesicles Position Complexin to Block Spontaneous Fusion

Rachel T. Wragg, David Snead, Yongming Dong, +5

Neuron

Membrane FusionBlock Spontaneous FusionMolecular BiologyProtein TransportIntracellular Trafficking +2

Motor Mechanism for Protein Threading through Hsp104

Petra Wendler, James Shorter, David Snead, +4

Molecular Cell

Membrane curvature sensing by the C-terminal domain of complexin

David Snead, Rachel T. Wragg, Jeremy S. Dittman, +1

Nature Communications

Membrane StructureMembrane Curvature SensingProteinlipid InteractionMembrane BiophysicsBiochemistry +5

Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

David Snead, Mariusz Matyszewski, Andrea M. Dickey, +3

Nature Structural & Molecular Biology

Mediate Microtubule BindingProtein FunctionSignal TransductionMolecular NeuroscienceSynaptic Signaling +13

Probing Structural Transitions in the Intrinsically Disordered C-Terminal Domain of the Measles Virus Nucleoprotein by Vibrational Spectroscopy of Cyanylated Cysteines

Connor G. Bischak, Sonia Longhi, David Snead, +3

Biophysical Journal

Cyanylated CysteinesMeasles Virus NucleoproteinVirus StructureProtein AssemblyBiochemistry +7

Conserved Distal Loop Residues in the Hsp104 and ClpB Middle Domain Contact Nucleotide-binding Domain 2 and Enable Hsp70-dependent Protein Disaggregation

Morgan E. DeSantis, Elizabeth A. Sweeny, David Snead, +5

Journal of Biological Chemistry

Protein FunctionSignal TransductionSignal RecognitionMolecular BiologyMedicine +1

The accessory helix of complexin functions by stabilizing central helix secondary structure

Daniel T Radoff, Yongming Dong, David Snead, +3

eLife

Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins

Rachel T. Wragg, Daniel Parisotto, Zhenlong Li, +6

Frontiers in Molecular Neuroscience