Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Robin Sherrington, Yuh‐Jin Liang, Ekaterina Rogaeva, +28

Nature

Neurodegenerative DiseasesEarly-onset Familial AlzheimerAlzheimer's DiseaseGenetic DisorderGenetics +5

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

Robin Sherrington, Ekaterina Rogaeva, Georges Lévesque, +17

Nature

Disease HeterogeneityAlzheimer's DiseaseMendelian DisorderGenetic DisorderGenetics +8

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

Ruoning Wang, Christopher P. Dillon, Lewis Z. Shi, +8

Immunity

Transcriptional RegulationT Lymphocyte ActivationLymphocyte DevelopmentMetabolic ReprogrammingT-regulatory Cell +10

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Lewis Z. Shi, Ruoning Wang, Gonghua Huang, +4

The Journal of Experimental Medicine

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

Hu Zeng, Kai Yang, Caryn Cloer, +3

Nature

Signal TransductionImmune DysregulationAdaptive Immune SystemMetabolic ProgrammingT-regulatory Cell +13

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

Bing Bai, Xusheng Wang, Yuxin Li, +31

Neuron

Proteomic TechnologyNeuroimaging BiomarkersNeurodegenerative DiseasesMolecular NeuroscienceAlzheimer's Disease +9

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

Hongbo Chi, Sean Barry, Rachel J. Roth, +4

Proceedings of the National Academy of Sciences

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

Jun Wei, Lingyun Long, Kai Yang, +8

Nature Immunology

Cell AutophagyMitophagySignal TransductionAutoimmune DiseaseT-regulatory Cell +12

Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

Jun Wei, Lingyun Long, Wenting Zheng, +14

Nature

Cancer TherapyCancer ImmunosurveillanceNovel TherapyImmunologyImmune Checkpoint Inhibitor +7

Lipid signalling enforces functional specialization of Treg cells in tumours

Seon Ah Lim, Jun Wei, Thanh-Long M. Nguyen, +9

Nature

Signal TransductionSignaling PathwayCell RegulationCell InteractionPathology +8