mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

Hu Zeng, Kai Yang, Caryn Cloer, +3

Nature

Signal TransductionImmune DysregulationAdaptive Immune SystemMetabolic ProgrammingT-regulatory Cell +13

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

Jun Wei, Lingyun Long, Kai Yang, +8

Nature Immunology

Cell AutophagyMitophagySignal TransductionAutoimmune DiseaseT-regulatory Cell +12

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

Chengxian Xu, Shaogang Sun, Travis S. Johnson, +4

Cell Reports

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

Kai Yang, Sharad Shrestha, Hu Zeng, +6

Immunity

Signal TransductionTh2 Cells DependCell DivisionRaptor-mtorc1-mediated Metabolic ReprogrammingCell Regulation +10

Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

Haiyan Tan, Kai Yang, Yuxin Li, +10

Immunity

Signal TransductionSignaling PathwayMedicineT-regulatory CellCellular Regulatory Mechanism +6

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

Sharad Shrestha, Kai Yang, Cliff Guy, +3

Nature Immunology

Signal TransductionSignaling PathwayT-regulatory CellImmunologyRegulatory T Cells +9

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

Guangwei Liu, Kai Yang, Samir Burns, +2

Nature Immunology

Signal TransductionSignaling PathwayCell RegulationT-regulatory CellS1p1-mtor Axis +7

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

Kai Yang, Geoffrey Neale, Douglas R. Green, +2

Nature Immunology

Cancer ImmunosurveillanceImmune HomeostasisNaive T CellsLymphocyte DevelopmentT-regulatory Cell +10

Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity

Peer W. F. Karmaus, Xiang Chen, Seon Ah Lim, +14

Nature

Lineage PlasticityCell LineageDevelopmental BiologyMedicineStem Cell Research +7

Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling

Kai Yang, Daniel Bastardo Blanco, Geoffrey Neale, +9

Nature

Functional FitnessSystems BiologySignal TransductionHomeostatic ControlSignaling Pathway +10