Jose M. Orozco

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

Stephen C.J. Parker, Michael L. Stitzel, D. Leland Taylor et al. · Proceedings of the National Academy of Sciences · 2013 · 741 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

SAMTOR is an <i>S</i> -adenosylmethionine sensor for the mTORC1 pathway

Xin Gu, Jose M. Orozco, Robert A. Saxton et al. · Science · 2017 · 545 citations · Full text

Life Sciences, Biochemistry, Physiology +17

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco et al. · Cell Reports · 2014 · 452 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Rachel L. Wolfson, Lynne Chantranupong, Gregory A. Wyant et al. · Nature · 2017 · 320 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +5

Dihydroxyacetone phosphate signals glucose availability to mTORC1

Jose M. Orozco, Patrycja A. Krawczyk, Sonia M. Scaria et al. · Nature Metabolism · 2020 · 235 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9