Science · 2017 · 545 citations · 36 references
Life SciencesBiochemistryPhysiologyMetabolic RegulationMetabolismSignal TransductionAmino Acid MetabolismEnergy MetabolismMetabolic SignalingNutrient SensingNutrient-sensing PathwaysProtein MetabolismAmino Acid Sensing PathwaysMammalian Target Of Rapamycin SignalingMethionine DeficiencyMethionine MetabolismMethionine RequirementMtor Complex 1 RegulationMtor Complex 1 SignalingMtor Signaling
Methionine influences animal physiology, and low‑methionine diets are linked to increased longevity and improved glucose homeostasis. The study aims to identify a molecular link between methionine restriction and mTORC1, a key regulator of lifespan and healthspan. The authors identify SAMTOR as a component of the nutrient‑sensing pathway upstream of mTORC1. SAMTOR directly binds S‑adenosylmethionine and is required for mTORC1 regulation in response to methionine. Gu et al., Science, p.
SAMTOR joins the family The amino acid methionine is widely appreciated to have interesting effects on animal physiology. Diets low in methionine increase longevity and overall health, particularly glucose homeostasis. Gu et al. describe a potential molecular link between the effects of methionine restriction and the growth controller mTOR complex 1 (mTORC1), a well-validated regulator of life span and health span in many organisms. They identify a protein that they named SAMTOR as a component of the nutrient-sensing pathway upstream of mTORC1. SAMTOR directly binds S-adenosylmethionine (SAM), a metabolite made from methionine, and is necessary for regulating mTORC1 in response to methionine. Science , this issue p. 813
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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Yasemin Sancak, Timothy R. Peterson, Yoav D. Shaul et al. · Science · 2008 · 2.8K citations