Jonathan P. Hutchinson

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

Damian J. Mole, Scott P. Webster, Iain Uings et al. · Nature Medicine · 2016 · 155 citations · Full text

Inflammation, Acute Pancreatitis, Pancreatic Cancer +9

Whole Cell Target Engagement Identifies Novel Inhibitors of <i>Mycobacterium tuberculosis</i> Decaprenylphosphoryl-β-<scp>d</scp>-ribose Oxidase

Sarah M. Batt, Mónica Cacho Izquierdo, Julia Castro Pichel et al. · ACS Infectious Diseases · 2015 · 65 citations · Full text

Tuberculosis Prevention, Molecular Biology, Single Point Mutation +17

Development of a small molecule that corrects misfolding and increases secretion of Z α ₁ ‐antitrypsin

David A. Lomas, James A. Irving, Christopher C. Arico-Muendel et al. · EMBO Molecular Medicine · 2021 · 62 citations · Full text

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

Jonathan P. Hutchinson, Paul Rowland, Mark R D Taylor et al. · Nature Communications · 2017 · 45 citations · Full text

Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation

John Liddle, Jonathan P. Hutchinson, Semra Kitchen et al. · Journal of Medicinal Chemistry · 2020 · 43 citations · Full text