Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel.

Neil Desai, Vuong Trieu, Zhiwen Yao, +12

Clinical Cancer Research

Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione

Robert F. Ozols, Karen G. Louie, Jacqueline Plowman, +4

Biochemical Pharmacology

Buthionine Sulfoximine DepletionOncogenic AgentMedicineHuman Ovarian CancerAnti-cancer Agent +7

Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice.

Jacqueline Plowman, V. L. Narayanan, Donald J. Dykes, +4

PubMed

PathologyPharmacotherapyTumor ImplantationTumor BiologyOncology +14

2-Substituted Aminopyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

S. KLUTCHKO, James M. Hamby, Diane H. Boschelli, +22

Journal of Medicinal Chemistry

Furan-Induced Hepatic Cholangiocarcinomas in Fischer 344 Rats

Robert R. Maronpot, Herschell D. Giles, Donald J. Dykes, +1

Toxicologic Pathology

Male F344 RatsGastroenterologyPathologyProgressive GrowthFischer 344 +15

Toxicity and anticancer activity of a new triazine antifolate (NSC 127755).

Thomas H. Corbett, Wilbur R. Leopold, Donald J. Dykes, +3

PubMed

Therapeutic SynergismPharmacotherapyPharmaceutical ChemistryTumor BiologyMedicinal Chemistry +14

The mechanism of action of docetaxel (Taxotere®) in xenograft models is not limited to bcl-2 phosphorylation

Lisa A. Kraus, Shanti K. Samuel, Steven M. Schmid, +3

Investigational New Drugs

Molecular PharmacologySignal TransductionSignaling PathwayMedicineXenograft Models +7

Encapsulation of the topoisomerase I inhibitor GL147211C in pegylated (STEALTH) liposomes: pharmacokinetics and antitumor activity in HT29 colon tumor xenografts.

G T Colbern, Donald J. Dykes, C Engbers, +9

PubMed

Tumor BiologyMedicinal ChemistryDrug TargetingOncologyAntitumor Activity +13

Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts

Patrick W. Vincent, Alex Bridges, Donald J. Dykes, +8

Cancer Chemotherapy and Pharmacology

OncologyHuman Tumor XenograftsMedicinePathologyTumor Targeting +7

Response of human tumor xenografts in athymic nude mice to docetaxel (RP 56976, Taxotere®)

Donald J. Dykes, Marie Christine Bissery, Steadman D. Harrison, +1

Investigational New Drugs

Tumor BiologyAthymic Nude MiceHuman Tumor XenograftsRp 56976Medicine +8