Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Anna Segerman, Mia Niklasson, Caroline Haglund, +18

Cell Reports

Clonal VariationNeural Stem CellHigh-grade GliomasCancer BiologyGlioma +19

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Yiwen Jiang, Voichita D. Marinescu, Yuan Xie, +13

Cell Reports

Piperlongumine induces inhibition of the ubiquitin–proteasome system in cancer cells

Malin Jarvius, Mårten Fryknäs, Pádraig D’Arcy, +7

Biochemical and Biophysical Research Communications

Tumor BiologyUbiquitin–proteasome SystemMedicinePharmacologyCancer Cell Biology +7

Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity

Mia Niklasson, Tobias Bergström, Malin Jarvius, +7

The Journal of Pathology

Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Walid Fayad, Linda Rickardson, Caroline Haglund, +5

Chemical Biology & Drug Design

NanotherapeuticsChemoprevention StrategyApoptosisCell DeathAnticancer Drug Screening +19

The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

Malin Wickström, Caroline Haglund, Henrik Lindman, +3

Investigational New Drugs

Prodrug J1Medicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +8

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

Caroline Haglund, Anna Åleskog, Peter Nygren, +5

Cancer Chemotherapy and Pharmacology

Normal TissuesOncologyMedicineClinical ActivityTumor Cells +8

Screening of an annotated compound library for drug activity in a resistant myeloma cell line

Linda Rickardson, Mårten Fryknäs, Caroline Haglund, +5

Cancer Chemotherapy and Pharmacology

Drug ActivityMedicinal ChemistryDrug TargetHealth SciencesMedicine +9

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Jenny Felth, Karolina Lesiak-Mieczkowska, Pádraig D’Arcy, +7

Investigational New Drugs

Tumor BiologyChemoprevention StrategyMedicineApoptosisPharmacology +10

The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing

Caroline Haglund, Anna Åleskog, Lena Håkansson, +4

Toxicology Letters

MedicineBioanalysisHematologyPreclinical HematotoxicityPathology +6