De novo NAD+ synthesis enhances mitochondrial function and improves health

Elena Katsyuba, Adrienne Mottis, Marika Ziętak, +16

Nature

Mitochondrial FunctionBiochemistryMitochondrial DynamicMitochondrial BiologyMetabolic Remodeling +6

Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication

Marco Gargaro, Giulia Scalisi, Giorgia Manni, +27

Immunity

Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure–Activity Relationship, X-ray Crystal Structure, and Anticancer Activity

S. Moniot, Mariantonietta Forgione, Alessia Lucidi, +11

Journal of Medicinal Chemistry

Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy

Marsha Pellegrino, Francesca Mancini, Rossella Lucà, +18

Cancer Research

Tumor BiologyPromising ApproachP53 FunctionDrug TargetingMdm2/mdm4 Heterodimer +13

α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD⁺) Biosynthesis

Roberto Pellicciari, Paride Liscio, Nicola Giacchè, +7

Journal of Medicinal Chemistry

Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based ω-acidic amino acids as glutamate receptors ligands

Rosanna Filosa, Maria Carmela Fulco, Maura Marinozzi, +8

Bioorganic & Medicinal Chemistry

BiochemistryFunctional SelectivityMedicineNovel BicycloBiological Evaluation +4

Bulky 1,4-benzoxazine derivatives with antifungal activity

Renata Fringuelli, Nicola Giacchè, Lara Milanese, +5

Bioorganic & Medicinal Chemistry

Antifungal AgentDerivativesMedicineAntifungal AgentsAntimicrobial Compound +3

Probing the Binding Site of Bile Acids in TGR5

Antonio Macchiarulo, Antimo Gioiello, Charles Thomas, +9

ACS Medicinal Chemistry Letters

Proteinlipid InteractionG-protein-coupled ReceptorMolecular BiologyBas BindBinding Site +14

Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies

Mariagrazia Rullo, Marco Cipolloni, Marco Catto, +9

Journal of Medicinal Chemistry

Targeting the Conformational Transitions of MDM2 and MDMX: Insights into Dissimilarities and Similarities of p53 Recognition

Antonio Macchiarulo, Nicola Giacchè, Andrea Carotti, +3

Journal of Chemical Information and Modeling

Structural BioinformaticsBiomolecular Structure PredictionMolecular BiologyMolecular CharacterizationProtein Folding +14