Nicola Giacchè

De novo NAD+ synthesis enhances mitochondrial function and improves health

Elena Katsyuba, Adrienne Mottis, Marika Ziętak et al. · Nature · 2018 · 427 citations · Full text

Mitochondrial Function, Biochemistry, Mitochondrial Dynamic +8

Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication

Marco Gargaro, Giulia Scalisi, Giorgia Manni et al. · Immunity · 2022 · 106 citations · Full text

Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure–Activity Relationship, X-ray Crystal Structure, and Anticancer Activity

S. Moniot, Mariantonietta Forgione, Alessia Lucidi et al. · Journal of Medicinal Chemistry · 2017 · 103 citations · Full text

Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy

Marsha Pellegrino, Francesca Mancini, Rossella Lucà et al. · Cancer Research · 2015 · 46 citations

Tumor Biology, Promising Approach, P53 Function +15

α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD⁺) Biosynthesis

Roberto Pellicciari, Paride Liscio, Nicola Giacchè et al. · Journal of Medicinal Chemistry · 2018 · 42 citations · Full text