Aryl hydrocarbon receptor control of a disease tolerance defence pathway

Alban Bessede, Marco Gargaro, Maria Teresa Pallotta, +35

Nature

Disease MechanismMedicineImmunologyReceptor (Biochemistry)Mechanism Of Action +6

WDFY4 is required for cross-presentation in response to viral and tumor antigens

Derek J. Theisen, Jesse T. Davidson, Carlos G. Briseño, +17

Science

Optimizing therapeutic outcomes of immune checkpoint blockade by a microbial tryptophan metabolite

Giorgia Renga, Emilia Nunzi, Marilena Pariano, +15

Journal for ImmunoTherapy of Cancer

DysbiosisHost-microbe InteractionsImmunologyAntimicrobial ChemotherapyImmune Checkpoint Blockade +19

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

Leonie Zeitler, Alessandra Fiore, Claudia Meyer, +11

eLife

Anti-ferroptotic MechanismLipid PeroxidationImmunologyAmino Acid OxidaseCell Death +14

An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development

Prachi Bagadia, Xiao Huang, Tiantian Liu, +14

Nature Immunology

Transcriptional RegulationSignal TransductionCdc1 DevelopmentSignaling PathwayCell Regulation +9

Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication

Marco Gargaro, Giulia Scalisi, Giorgia Manni, +27

Immunity

Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation

Giada Mondanelli, Alice Coletti, Francesco Greco, +28

Proceedings of the National Academy of Sciences

Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells

Marco Gargaro, Carmine Vacca, Serena Massari, +20

Frontiers in Immunology

Distinct roles of immunoreceptor tyrosine‐based motifs in immunosuppressive indoleamine 2,3‐dioxygenase 1

Elisa Albini, V. Rosini, Marco Gargaro, +12

Journal of Cellular and Molecular Medicine

Altered compensatory cytokine signaling underlies the discrepancy between <i>Flt3–/–</i> and <i>Flt3l–/–</i> mice

Vivek Durai, Prachi Bagadia, Carlos G. Briseño, +7

The Journal of Experimental Medicine