Aryl hydrocarbon receptor control of a disease tolerance defence pathway

Alban Bessede, Marco Gargaro, Maria Teresa Pallotta, +35

Nature

Disease MechanismMedicineImmunologyReceptor (Biochemistry)Mechanism Of Action +6

Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression

Lucile Vanhersecke, Maxime Brunet, Jean‐Philippe Guégan, +30

Nature Cancer

Lymphoid NeoplasiaCancer ImmunosurveillancePd-l1 ExpressionSolid TumorsMedicine +7

Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas

Maud Toulmonde, Nicolas Penel, Julien Adam, +12

JAMA Oncology

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

Marie Favennec, Benjamin Hennart, Robert Caïazzo, +15

Obesity

Metabolic DisorderHuman ObesityMetabolic RemodelingInsulin SignalingObesity +24

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

Chai K. Lim, Ayse Bilgin, David B. Lovejoy, +6

Scientific Reports

Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort

Antoîne Italiano, Alban Bessede, M. Pulido, +17

Nature Medicine

Lymphoid NeoplasiaPembrosarc Trial CohortMedicineSoft-tissue SarcomasImmunology +5

Programmed cell death 1 (PD-1) targeting in patients with advanced osteosarcomas: results from the PEMBROSARC study

Axel Le Cesne, Perrine Marec‐Bérard, Jean‐Yves Blay, +13

European Journal of Cancer

MedicineApoptosisCell DeathPathologyAdvanced Osteosarcomas +6

Regorafenib-Avelumab Combination in Patients with Microsatellite Stable Colorectal Cancer (REGOMUNE): A Single-arm, Open-label, Phase II Trial

Sophie Cousin, Coralie Cantarel, Jean‐Philippe Guégan, +11

Clinical Cancer Research

Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies

Mathieu Larroquette, Jean‐Philippe Guégan, Benjamin Besse, +11

Journal for ImmunoTherapy of Cancer

In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains

Fabio Cavaliere, Loïc Cerf, Benjamin Dehay, +8

Neurobiology of Disease

Neurodegenerative DiseasesParkinson Disease BrainsMedicineNeuropharmacologyDegenerative Pathology +9