MDM4 (MDMX) localizes at the mitochondria and facilitates the p53‐mediated intrinsic‐apoptotic pathway

Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, +12

The EMBO Journal

Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant

Emmanuel de Billy, Marsha Pellegrino, Domenico Orlando, +25

Neuro-Oncology

Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity

Emanuela Teveroni, Marsha Pellegrino, Sabrina Sacconi, +14

Journal of Clinical Investigation

Human GrowthGeneticsEstrogen EffectsGynecologyFemale Reproductive Function +24

T lymphocyte-mediated cytotoxicity against autologous EBV-genome-bearing B cells.

Constantine D. Tsoukas, Robert I. Fox, Susan F. Slovin, +7

The Journal of Immunology

Adaptive Immune SystemLow ResponseImmunologyAntiviral ResponseVirology +9

Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy

Marsha Pellegrino, Francesca Mancini, Rossella Lucà, +18

Cancer Research

Tumor BiologyPromising ApproachP53 FunctionDrug TargetingMdm2/mdm4 Heterodimer +13

Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53

Agata Desantis, Tiziana Bruno, Valeria Catena, +20

Cell Death and Disease

Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes

Valentina Perri, Marsha Pellegrino, Francesca Ceccacci, +7

PLoS ONE

Autoimmune DiseaseCationic LiposomesT-regulatory CellImmunologyGene Expression +13

Manipulating the tumor immune microenvironment to improve cancer immunotherapy: IGF1R, a promising target

Marsha Pellegrino, Valerio Secli, Silvia D’Amico, +8

Frontiers in Immunology

ImmunologyImmune RegulationBiological MicroenvironmentsAnti-tumor ImmunityImmune Cell Therapy +15

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents

Nadia Canu, Ilaria Pagano, Luca Rosario La Rosa, +10

Frontiers in Molecular Neuroscience

Identification and functional characterization of CD8+ T regulatory cells in type 1 diabetes patients

Marsha Pellegrino, Antonino Crinò, M. Manuela Rosado, +1

PLoS ONE

Type 1Control GroupLong-term Type 1Autoimmune DiseaseT-regulatory Cell +11