Brenda Burton

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action

Olivier René, Benjamin P. Fauber, Gladys de Leon Boenig et al. · ACS Medicinal Chemistry Letters · 2014 · 82 citations · Full text

Rorc Agonists, Minor Structural Change, Pharmacotherapy +19

The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy

Iain M. McLay, Frank Halley, John E. Souness et al. · Bioorganic & Medicinal Chemistry · 2001 · 78 citations

Rheumatoid Disorder, Rheumatology, Anti-inflammatory +8

Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc

Benjamin P. Fauber, Gladys de Leon Boenig, Brenda Burton et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 62 citations · Full text

Fluorous Synthesis, Structure-based Design, Molecule-based Material +1

Reduction in lipophilicity improved the solubility, plasma–protein binding, and permeability of tertiary sulfonamide RORc inverse agonists

Benjamin P. Fauber, Olivier René, Gladys de Leon Boenig et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 49 citations · Full text

Molecular Pharmacology, Pharmaceutical Science, Proteinlipid Interaction +11

Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479

Kirk Robarge, Wendy Lee, Charles Eigenbrot et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 38 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +9