Frank Halley

Functionalization of saturated hydrocarbons. 14. Further studies on the mechanism of Gif-type systems

Derek H. R. Barton, Frank Halley, Nubar Ozbalik et al. · Journal of the American Chemical Society · 1989 · 115 citations

Altmetrics, Petroleomics, Gif-type Systems +12

Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers

Victor Certal, Jean‐Christophe Carry, Frank Halley et al. · Journal of Medicinal Chemistry · 2014 · 83 citations · Full text

Compound 28, New Series, Chemical Biology +18

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3<i>S</i>)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7<i>H</i>-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer

Youssef El‐Ahmad, Michel Tabart, Frank Halley et al. · Journal of Medicinal Chemistry · 2019 · 80 citations · Full text

The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy

Iain M. McLay, Frank Halley, John E. Souness et al. · Bioorganic & Medicinal Chemistry · 2001 · 78 citations

Rheumatoid Disorder, Rheumatology, Anti-inflammatory +8

An Algorithm-Directed Two-Component Library Synthesized Via Solid-Phase Methodology Yielding Potent and Orally Bioavailable p38 MAP Kinase Inhibitors

Jeffrey M. McKenna, Frank Halley, John E. Souness et al. · Journal of Medicinal Chemistry · 2002 · 73 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Drug Target +13