Functionalization of saturated hydrocarbons. 14. Further studies on the mechanism of Gif-type systems

Derek H. R. Barton, Frank Halley, Nubar Ozbalik, +3

Journal of the American Chemical Society

AltmetricsPetroleomicsGif-type SystemsEngineeringDonut Icon +10

Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers

Victor Certal, Jean‐Christophe Carry, Frank Halley, +33

Journal of Medicinal Chemistry

Compound 28New SeriesChemical BiologyPharmaceutical ChemistryPi3kβ Inhibitors +16

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3<i>S</i>)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7<i>H</i>-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer

Youssef El‐Ahmad, Michel Tabart, Frank Halley, +37

Journal of Medicinal Chemistry

The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy

Iain M. McLay, Frank Halley, John E. Souness, +23

Bioorganic & Medicinal Chemistry

Rheumatoid DisorderRheumatologyAnti-inflammatoryMedicineOsteoarthritis +6

An Algorithm-Directed Two-Component Library Synthesized Via Solid-Phase Methodology Yielding Potent and Orally Bioavailable p38 MAP Kinase Inhibitors

Jeffrey M. McKenna, Frank Halley, John E. Souness, +5

Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryDrug TargetBioorganic ChemistryPermeability Assays +11

The chemistry of pentavalent organobismuth reagents. Part 7. The possible role of radical mechanisms in the phenylation process for bismuth(V), and related lead(IV), lodine(III), and antimony(V) reagents

Derek H. R. Barton, Jean‐Pierre Finet, Charles Giannotti, +1

Journal of the Chemical Society Perkin Transactions 1

Inorganic ChemistryEngineeringBiochemistryNatural SciencesRadical (Chemistry) +10

SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models

Maysoun Shomali, Jane Cheng, Fangxian Sun, +27

Molecular Cancer Therapeutics

Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kβ Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers

Victor Certal, Frank Halley, Angéla Virone-Oddos, +24

Journal of Medicinal Chemistry

Single Pi3kTumor Growth DelayKinase InhibitorsPharmacotherapyPharmaceutical Chemistry +19

RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

Alan Collis, Martyn Foster, Frank Halley, +6

Bioorganic & Medicinal Chemistry Letters

Vitro PotencyP38 Inhibitor Rpr200765aBiochemistryMedicineNatural Sciences +9

Selective ET_AAntagonists. 5. Discovery and Structure−Activity Relationships of Phenoxyphenylacetic Acid Derivatives

Peter C. Astles, Thomas J. Brown, Frank Halley, +11

Journal of Medicinal Chemistry

Receptor AntagonistOrganic ChemistryPharmacotherapyChemical DerivativePharmaceutical Chemistry +14