Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Mali Jiang, Jiawei Wang, Jinrong Fu, +27

Nature Medicine

Mammalian ModelsGeneticsCell DeathDegenerative PathologyNeuroprotection +6

trans-(−)-ε-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease

Jinrong Fu, Jing Jin, Robert H. Cichewicz, +9

Journal of Biological Chemistry

Neurodegenerative DiseasesSystems BiologyMolecular PhysiologySignal TransductionMitochondrial Function +11

Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene

Yufang Weng, Lan Xiang, Akira Matsuura, +3

Bioorganic & Medicinal Chemistry

BiosynthesisEngineeringBiochemistryMedicinal FungiYeast +3

Baicalein reduces E46K α‐synuclein aggregation <i>in vitro</i> and protects cells against E46K α‐synuclein toxicity in cell models of familiar Parkinsonism

Mali Jiang, Yair Porat‐Shliom, Zhong Pei, +12

Journal of Neurochemistry

Anti-Aging Effects of Phloridzin, an Apple Polyphenol, on Yeast<i>via</i>the SOD and Sir2 Genes

Lan Xiang, Kaiyue Sun, Jun Lü, +4

Bioscience Biotechnology and Biochemistry

Gastrodin From Gastrodia elata Enhances Cognitive Function and Neuroprotection of AD Mice via the Regulation of Gut Microbiota Composition and Inhibition of Neuron Inflammation

Opeyemi B. Fasina, Jianyu Wang, Jian‐Xia Mo, +5

Frontiers in Pharmacology

Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor

Lan Xiang, Yukiko Nakamura, Young‐Mi Lim, +7

Aging

Lipid PeroxidationRedox BiologyOxidative StressDrosophila MelanogasterLife Span +15

Circ-IGF1R has pro-proliferative and anti-apoptotic effects in HCC by activating the PI3K/AKT pathway

Hangwei Fu, Lin Xia, Yuanxin Zhu, +6

Gene

Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in <i>Drosophila</i> testes

Jun Yu, Lan Xiang, Xia Chen, +6

Development

SpermatogenesisGeneticsMolecular GeneticsStem Cell BiologyEpigenetics +18

Ganodermasides C and D, Two New Anti-Aging Ergosterols from Spores of the Medicinal Mushroom<i>Ganoderma lucidum</i>

Yufang Weng, Jun Lu, Lan Xiang, +4

Bioscience Biotechnology and Biochemistry

Lifespan ExtensionOxysterolAgingBiochemistryLongevity +11