Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor

Boris Brus, Urban Košak, Samo Turk, +6

Journal of Medicinal Chemistry

Development of an in-vivo active reversible butyrylcholinesterase inhibitor

Urban Košak, Boris Brus, Damijan Knez, +22

Scientific Reports

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Urban Košak, Boris Brus, Damijan Knez, +15

Journal of Medicinal Chemistry

Combinatorial ChemistryScopolamine ModelNeurochemical BiomarkersChemical BiologyPharmaceutical Chemistry +21

Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease

Damijan Knez, Marko Jukič, Xavier Brazzolotto, +8

Chemical Communications

Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities

Damijan Knez, Nicolas Coquelle, Anja Pišlar, +9

European Journal of Medicinal Chemistry

Alzheimer's DiseaseBiochemistryButyrylcholinesterase InhibitorsMedicineNeuroprotective Activities +7

Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties

Natalia Guzior, Marek Bajda, Mirosław Skrok, +7

European Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryHeterodimeric Isoindoline-1,3-dione DerivativesMedicineNatural Sciences +7

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents

Urban Košak, Damijan Knez, Nicolas Coquelle, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseMedicineNaphthalene-2-sulfonamide MoietiesPharmacological Agent +5

N-alkylpiperidine carbamates as potential anti-Alzheimer’s agents

Urban Košak, Nika Strašek, Damijan Knez, +8

European Journal of Medicinal Chemistry

Alzheimer's DiseaseN-alkylpiperidine CarbamatesMedicinePharmacological AgentNeuropharmacology +3

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents

Dawid Panek, Anna Więckowska, Jakub Jończyk, +13

ACS Chemical Neuroscience

Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells

Anja Pišlar, Nace Zidar, D. Kikelj, +1

Neuropharmacology

Signal TransductionMedicineApoptosisAutophagyCell Death +6