Boris Brus

Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor

Boris Brus, Urban Košak, Samo Turk et al. · Journal of Medicinal Chemistry · 2014 · 268 citations · Full text

Development of an in-vivo active reversible butyrylcholinesterase inhibitor

Urban Košak, Boris Brus, Damijan Knez et al. · Scientific Reports · 2016 · 159 citations · Full text

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Urban Košak, Boris Brus, Damijan Knez et al. · Journal of Medicinal Chemistry · 2017 · 151 citations · Full text

Combinatorial Chemistry, Scopolamine Model, Neurochemical Biomarkers +23

LiSiCA: A Software for Ligand-Based Virtual Screening and Its Application for the Discovery of Butyrylcholinesterase Inhibitors

Samo Lešnik, Tanja Štular, Boris Brus et al. · Journal of Chemical Information and Modeling · 2015 · 93 citations

Drug Target, Bioorganic Chemistry, Hit Identification +16

Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties

Natalia Guzior, Marek Bajda, Mirosław Skrok et al. · European Journal of Medicinal Chemistry · 2015 · 68 citations · Full text

Medicinal Chemistry, Biochemistry, Heterodimeric Isoindoline-1,3-dione Derivatives +9