Development of an in-vivo active reversible butyrylcholinesterase inhibitor

Urban Košak, Boris Brus, Damijan Knez, +22

Scientific Reports

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Urban Košak, Boris Brus, Damijan Knez, +15

Journal of Medicinal Chemistry

Combinatorial ChemistryScopolamine ModelNeurochemical BiomarkersChemical BiologyPharmaceutical Chemistry +21

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

Dawid Panek, Anna Więckowska, Tomasz Wichur, +10

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryNew PhthalimideDerivative (Chemistry)Biochemistry +7

LiSiCA: A Software for Ligand-Based Virtual Screening and Its Application for the Discovery of Butyrylcholinesterase Inhibitors

Samo Lešnik, Tanja Štular, Boris Brus, +4

Journal of Chemical Information and Modeling

Drug TargetBioorganic ChemistryHit IdentificationChemical BiologyMedicinal Chemistry +14

Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease

Damijan Knez, Marko Jukič, Xavier Brazzolotto, +8

Chemical Communications

Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities

Damijan Knez, Nicolas Coquelle, Anja Pišlar, +9

European Journal of Medicinal Chemistry

Alzheimer's DiseaseBiochemistryButyrylcholinesterase InhibitorsMedicineNeuroprotective Activities +7

Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT 6 receptor antagonists. Design, synthesis and biological evaluation

Anna Więckowska, Marcin Kołaczkowski, Adam Bucki, +14

European Journal of Medicinal Chemistry

Molecular PharmacologyNeurodegenerative DiseasesDrug TargetAlzheimer's DiseaseNovel Multi-target-directed Ligands +9

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents

Urban Košak, Damijan Knez, Nicolas Coquelle, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseMedicineNaphthalene-2-sulfonamide MoietiesPharmacological Agent +5

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

Damijan Knez, Boris Brus, Nicolas Coquelle, +6

Bioorganic & Medicinal Chemistry

Neurodegenerative DiseasesAlzheimer's DiseaseBiochemistryNitroxoline DerivativesMedicine +5

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease

Tomasz Wichur, Anna Więckowska, Krzysztof Więckowski, +9

European Journal of Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseBiochemistry1-Benzylpyrrolidine-3-amine-based Buche InhibitorsMedicine +9