Steven Orr

Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells

Eric C. Hales, Steven Orr, Amanda Larson Gedman et al. · Journal of Biological Chemistry · 2013 · 49 citations · Full text

6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors

Lei Wang, Adrianne Wallace-Povirk, Sudhir Raghavan et al. · Journal of Medicinal Chemistry · 2015 · 38 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Tumor Biology +19

Discovery of 5-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity

Shermaine Mitchell-Ryan, Yiqiang Wang, Sudhir Raghavan et al. · Journal of Medicinal Chemistry · 2013 · 32 citations · Full text

Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter

Lalit K. Golani, Christina George, Sai Zhao et al. · Journal of Medicinal Chemistry · 2014 · 26 citations · Full text

Novel 5-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor Agents

Yiqiang Wang, Shermaine Mitchell-Ryan, Sudhir Raghavan et al. · Journal of Medicinal Chemistry · 2015 · 25 citations · Full text