Eric C. Hales

Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter

Sita Kugel Desmoulin, Lei Wang, Eric C. Hales et al. · Molecular Pharmacology · 2011 · 60 citations · Full text

Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells

Eric C. Hales, Steven Orr, Amanda Larson Gedman et al. · Journal of Biological Chemistry · 2013 · 49 citations · Full text

Discovery of 5-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity

Shermaine Mitchell-Ryan, Yiqiang Wang, Sudhir Raghavan et al. · Journal of Medicinal Chemistry · 2013 · 32 citations · Full text