Shermaine Mitchell-Ryan

Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase

Lei Wang, Sita Kugel Desmoulin, Christina Cherian et al. · Journal of Medicinal Chemistry · 2011 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement

Ronald van Ree, Dexter Sapiter Ballerda, M. Cecilia Berin et al. · Frontiers in Allergy · 2021 · 64 citations · Full text

Life Sciences, Bioinformatics, Biology +15

Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for Cellular Uptake by High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier

Lei Wang, Christina Cherian, Sita Kugel Desmoulin et al. · Journal of Medicinal Chemistry · 2012 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors

Lei Wang, Adrianne Wallace-Povirk, Sudhir Raghavan et al. · Journal of Medicinal Chemistry · 2015 · 39 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of 5-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity

Shermaine Mitchell-Ryan, Yiqiang Wang, Sudhir Raghavan et al. · Journal of Medicinal Chemistry · 2013 · 33 citations

Medicine, Medicinal Chemistry, Pharmacology +14