Adrian Sievers‐Engler

Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping

Michael Juchum, Marcel Günther, Eva Döring et al. · Journal of Medicinal Chemistry · 2017 · 85 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond

Andreas Lange, Marcel Günther, Felix Michael Büttner et al. · Journal of the American Chemical Society · 2015 · 81 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +17

Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3

Felix Muth, Ahmed El‐Gokha, Francesco Ansideri et al. · Journal of Medicinal Chemistry · 2016 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Design, Synthesis, and Biological Evaluation of Novel Type I ¹ / ₂ p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine

Niklas M. Walter, Heike K. Wentsch, Mike Bührmann et al. · Journal of Medicinal Chemistry · 2017 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Methods for the comprehensive structural elucidation of constitution and stereochemistry of lipopeptides

Heike Gerhardt, Adrian Sievers‐Engler, Ghazaleh Jahanshah et al. · Journal of Chromatography A · 2015 · 33 citations

Life Sciences, Biochemistry, Chemistry +12