Eva Döring

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site

Marcel Günther, Jonas Lategahn, Michael Juchum et al. · Journal of Medicinal Chemistry · 2017 · 107 citations · Full text

Medicine, Oncology, Pharmacology +14

Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping

Michael Juchum, Marcel Günther, Eva Döring et al. · Journal of Medicinal Chemistry · 2017 · 85 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Development, Optimization, and Structure–Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4-<i>d</i>]pyrrolo[2,3-<i>b</i>]pyridine Scaffold

Michael Förster, A. Chaikuad, Teodor Dimitrov et al. · Journal of Medicinal Chemistry · 2018 · 59 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3

Felix Muth, Ahmed El‐Gokha, Francesco Ansideri et al. · Journal of Medicinal Chemistry · 2016 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

<i>Tetra</i>-Substituted Pyridinylimidazoles As Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and c-Jun <i>N</i>-Terminal Kinase 3 for Potential Treatment of Neurodegenerative Diseases

Felix Muth, Marcel Günther, Silke M. Bauer et al. · Journal of Medicinal Chemistry · 2014 · 52 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15