Marcel Günther

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site

Marcel Günther, Jonas Lategahn, Michael Juchum et al. · Journal of Medicinal Chemistry · 2017 · 107 citations · Full text

Medicine, Oncology, Pharmacology +14

Lung Cancer: EGFR Inhibitors with Low Nanomolar Activity against a Therapy‐Resistant L858R/T790M/C797S Mutant

Marcel Günther, Michael Juchum, Gerhard Kelter et al. · Angewandte Chemie International Edition · 2016 · 106 citations

Medicine, Oncology, Pharmacology +15

Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping

Michael Juchum, Marcel Günther, Eva Döring et al. · Journal of Medicinal Chemistry · 2017 · 85 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond

Andreas Lange, Marcel Günther, Felix Michael Büttner et al. · Journal of the American Chemical Society · 2015 · 81 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +17

Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors

David E. Heppner, Marcel Günther, Florian Wittlinger et al. · Journal of Medicinal Chemistry · 2020 · 65 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14