Marcel Günther

Lung Cancer: EGFR Inhibitors with Low Nanomolar Activity against a Therapy‐Resistant L858R/T790M/C797S Mutant

Marcel Günther, Michael Juchum, Gerhard Kelter et al. · Angewandte Chemie International Edition · 2016 · 102 citations

Drug Targeting, Oncology, Novel Therapy +15

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site

Marcel Günther, Jonas Lategahn, Michael Juchum et al. · Journal of Medicinal Chemistry · 2017 · 102 citations · Full text

Drug Target, Both Hydrophobic Regions, Chemical Biology +21

Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping

Michael Juchum, Marcel Günther, Eva Döring et al. · Journal of Medicinal Chemistry · 2017 · 82 citations · Full text

Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond

Andreas Lange, Marcel Günther, Felix Michael Büttner et al. · Journal of the American Chemical Society · 2015 · 80 citations

Gatekeeper Met146, Molecular Biology, Cell Death +24

Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors

David E. Heppner, Marcel Günther, Florian Wittlinger et al. · Journal of Medicinal Chemistry · 2020 · 63 citations · Full text

Imidazole Core, Drug Target, Chemical Biology +22