P B Jensen

Sequential coexpression of the multidrug resistance genes MRP and mdr1 and their products in VP-16 (etoposide)-selected H69 small cell lung cancer cells.

Ian W. Brock, David R. Hipfner, BS Nielsen et al. · PubMed · 1995 · 105 citations

Medicine, Molecular Biology, Oncology +13

Loss of amino acids 1490Lys-Ser-Lys1492 in the COOH-terminal region of topoisomerase IIalpha in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization.

Irene Wessel, P B Jensen, Jacob Falck et al. · PubMed · 1997 · 63 citations

Medicine, Molecular Biology, Oncology +13

Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.

Maxwell Sehested, Irene Wessel, Lars H. Jensen et al. · PubMed · 1998 · 54 citations

Medicine, Biochemistry, Pharmacology +14

Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.

Irene Wessel, Lars H. Jensen, P B Jensen et al. · PubMed · 1999 · 47 citations

Medicine, Oncology, Pharmacology +14

Relationship of VP-16 to the classical multidrug resistance phenotype.

Maxwell Sehested, Ellen Friche, P B Jensen et al. · PubMed · 1992 · 35 citations

Medicine, Biochemistry, Pharmacology +17