Quantitative Proteomic Analysis of Post-translational Modifications of Human Histones

Hans Christian Beck, Eva C. Nielsen, Rune Matthiesen, +6

Molecular & Cellular Proteomics

Histone ModificationsEpigenetic ChangeBiological Mass SpectrometryMolecular BiologyQuantitative Proteomic Analysis +18

A Novel Mechanism of Cell Killing by Anti-topoisomerase II Bisdioxopiperazines

Lars H. Jensen, Karin C. Nitiss, Angela Rose, +7

Journal of Biological Chemistry

Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy

Elke Martin, Annemette Thougaard, Morten Grauslund, +6

Toxicology

Medicinal ChemistryHeart FailurePharmacologyCardiovascular PharmacologyDoxorubicin-induced Cardiomyopathy +5

Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.

Maxwell Sehested, Irene Wessel, Lars H. Jensen, +6

PubMed

Molecular PharmacologyDrug Resistance AnalysisChemoprevention StrategyBiochemistryTopoisomerase Ii +12

Maleimide Is a Potent Inhibitor of Topoisomerase II in Vitro and in Vivo: A New Mode of Catalytic Inhibition

Lars H. Jensen, Axelle Renodon‐Cornière, Irene Wessel, +5

Molecular Pharmacology

Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.

Irene Wessel, Lars H. Jensen, P B Jensen, +5

PubMed

Tumor BiologyAlpha IsoformBisdioxopiperazine ResistanceBisdioxopiperazine DrugsMedicine +13

Substituted Purine Analogues Define a Novel Structural Class of Catalytic Topoisomerase II Inhibitors

Lars H. Jensen, Annemette Thougaard, Morten Grauslund, +7

Cancer Research

Atpase ReactionNovel Structural ClassMedicinal ChemistryPurine Analogues DefineCombinatorial Chemistry +12

Agrobacterium tumefaciens-mediated transformation of Brassica napus winter cultivars

Ove Damgaard, Lars H. Jensen, O. S. Rasmussen

Transgenic Research

A Mutation in Human Topoisomerase II α Whose Expression Is Lethal in DNA Repair-deficient Yeast Cells

Jerrylaine V. Walker, Karin C. Nitiss, Lars H. Jensen, +6

Journal of Biological Chemistry

Dna TopologyGeneticsMolecular BiologyMolecular GeneticsYeast +14

Stability of the Topoisomerase II Closed Clamp Conformation May Influence DNA-stimulated ATP Hydrolysis

Jerrylaine Vaughn, Sheng‐Li Huang, Irene Wessel, +6

Journal of Biological Chemistry

BiochemistryProtein FoldingTopoisomerase IiNatural SciencesAtp Hydrolysis Activity +8