Kristof Van Emelen

JNJ-26481585, a Novel Second-Generation Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity

Janine Arts, Peter King, Ann Marin et al. · Clinical Cancer Research · 2009 · 232 citations

Medicine, Oncology, Pharmacology +12

R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies

Janine Arts, Patrick Angibaud, Ann Mariën et al. · British Journal of Cancer · 2007 · 89 citations · Full text

Medicine, Oncology, Pharmacology +15

2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase

Tim H. M. Jonckers, Tse‐I Lin, Christophe Buyck et al. · Journal of Medicinal Chemistry · 2010 · 55 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Synthesis of cis-fused hexahydro-4aH-indeno[1,2-b]pyridines via intramolecular Ritter reaction and their conversion into tricyclic analogues of NK-1 and dopamine receptor ligands

Kristof Van Emelen, Tom De Wit, Georges J. Hoornaert et al. · Tetrahedron · 2002 · 40 citations

Natural Sciences, Chemistry, Medicinal Chemistry +14

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

Sandrine Vendeville, Tse‐I Lin, Lili Hu et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 39 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +16