Dean Shannon

Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships

Paul S. Charifson, Anne‐Laure Grillot, Trudy H. Grossman et al. · Journal of Medicinal Chemistry · 2008 · 222 citations · Full text

Bioorganic Chemistry, Antibacterial Activity, Molecular Biology +23

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases

Luc J. Farmer, Mark W. Ledeboer, Thomas Hoock et al. · Journal of Medicinal Chemistry · 2015 · 87 citations

Immunology, Immunologic Mechanism, Janus Tyrosine Kinases +16

Second-Generation Antibacterial Benzimidazole Ureas: Discovery of a Preclinical Candidate with Reduced Metabolic Liability

Anne‐Laure Grillot, Arnaud LeTiran, Dean Shannon et al. · Journal of Medicinal Chemistry · 2014 · 80 citations · Full text

Metabolomic Profiling, Reduced Metabolic Liability, Antimicrobial Chemotherapy +19

Studies Directed toward Asymmetric Synthesis of Cardioactive Steroids via Anionic Polycyclization

Zhixiang Yang, Dean Shannon, Vouy-Linh Truong et al. · Organic Letters · 2002 · 36 citations

Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2

Luc J. Farmer, Michael P. Clark, Michael J. Boyd et al. · ACS Medicinal Chemistry Letters · 2017 · 25 citations · Full text