Otmar Schaaf

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

Dong-Sung Kim, Lorenz Herdeis, Dorothea Rudolph et al. · Nature · 2023 · 448 citations · Full text

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

Laetitia J. Martin, Manfred Koegl, Gerd Bader et al. · Journal of Medicinal Chemistry · 2016 · 219 citations · Full text

Molecular Biology, Cancer Biology, Tumor Biology +17

Target-induced formation of neuraminidase inhibitors from <i>in vitro</i> virtual combinatorial libraries

Matthias Hochgürtel, Heiko Kroth, Dorothea Piecha et al. · Proceedings of the National Academy of Sciences · 2002 · 136 citations · Full text

Combinatorial Chemistry, Drug Target, Bioorganic Chemistry +17

Rapid and sensitive analysis of azadirachtin and related triterpenoids from Neem (Azadirachta indica) by high-performance liquid chromatography–atmospheric pressure chemical ionization mass spectrometry

Otmar Schaaf, Andrew P. Jarvis, S Esch et al. · Journal of Chromatography A · 2000 · 107 citations

Biochemistry, Medicine, Sensitive Analysis +9

Ketones as Building Blocks for Dynamic Combinatorial Libraries:  Highly Active Neuraminidase Inhibitors Generated via Selection Pressure of the Biological Target

Matthias Hochgürtel, Ralf Biesinger, Heiko Kroth et al. · Journal of Medicinal Chemistry · 2003 · 104 citations

Combinatorial Chemistry, Building Blocks, Target Enzyme +18