Matthias Hochgürtel

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models

Vijaykumar M. Baragi, Gabriele Becher, Alison M. Bendele et al. · Arthritis & Rheumatism · 2009 · 171 citations

Target-induced formation of neuraminidase inhibitors from <i>in vitro</i> virtual combinatorial libraries

Matthias Hochgürtel, Heiko Kroth, Dorothea Piecha et al. · Proceedings of the National Academy of Sciences · 2002 · 136 citations · Full text

Combinatorial Chemistry, Drug Target, Bioorganic Chemistry +17

Ketones as Building Blocks for Dynamic Combinatorial Libraries:  Highly Active Neuraminidase Inhibitors Generated via Selection Pressure of the Biological Target

Matthias Hochgürtel, Ralf Biesinger, Heiko Kroth et al. · Journal of Medicinal Chemistry · 2003 · 104 citations

Combinatorial Chemistry, Building Blocks, Target Enzyme +18

Structure–Activity Relationship of Inhibition of Fish Feeding by Sponge-derived and Synthetic Pyrrole–Imidazole Alkaloids

Thomas Lindel, Holger Hoffmann, Matthias Hochgürtel et al. · Journal of Chemical Ecology · 2000 · 88 citations

Synthesis of the Marine Natural Product Oroidin and Its <i>Z</i>-Isomer

Thomas Lindel, Matthias Hochgürtel · The Journal of Organic Chemistry · 2000 · 58 citations

Medicinal Chemistry, Engineering, Biochemistry +11