Discovery of [<i>cis</i>-3-({(5<i>R</i>)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1<i>H</i>-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5<i>H</i>)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist

Mitsunori Kono, Atsuko Ochida, Tsuneo Oda, +23

Journal of Medicinal Chemistry

PharmacotherapyPharmaceutical ChemistryPre-clinical PharmacologyMolecular PharmacologyMedicinal Chemistry +14

Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice

Takukyu Sha, Keiko Igaki, Masashi Yamasaki, +2

International Immunopharmacology

InflammationAllergyMucosal ImmunologyImmunologyGastroenterology +3

Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist

Akira Shibata, Keiko Uga, Takayuki Sato, +9

Biochemical Pharmacology

Molecular PharmacologyPharmacological Inhibitory ProfileMedicineImmunologyMechanism Of Action +4

MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model

Keiko Igaki, Yusaku Komoike, Yoshiki Nakamura, +7

International Immunopharmacology

InflammationCytokineImmune RegulationImmunologyChronic Inflammation +8

Synthesis and Biological Activities of 4-Phenyl-5-pyridyl-1,3-thiazole Derivatives as p38 MAP Kinase Inhibitors

Seiji Miwatashi, Yasuyoshi Arikawa, Ken‐ichi Naruo, +5

Chemical and Pharmaceutical Bulletin

ImmunologyBiological ActivitiesHeterocycle ChemistryInflammationMedicinal Chemistry +14

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy

Akira Shibata, Masako Kuno, Ryutaro Adachi, +9

PLoS ONE

Anti-fibrosis TherapyCatalytic DomainAntifibrotic TherapyPharmacotherapyDermatology +20

Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells

Yoshiki Nakamura, Keiko Igaki, Yusaku Komoike, +2

Inflammation Research

InflammationCytokineMucosal ImmunologyImmunologyPathology +8

Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease

Keiko Igaki, Yoshiki Nakamura, Masayuki Tanaka, +12

Inflammation Research

InflammationAnti-inflammatoryGastrointestinal PharmacologyMedicineImmune Regulation +9

Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model

Keiko Igaki, Yoshiki Nakamura, Yusaku Komoike, +6

Inflammation

InflammationAnti-inflammatoryGastrointestinal PharmacologyMedicineImmunology +8

Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by FcγR signaling

Yoshiki Nakamura, Kazumasa Yokoyama, Keiko Igaki, +1

International Immunopharmacology