Keiko Uga

Discovery of [<i>cis</i>-3-({(5<i>R</i>)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1<i>H</i>-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5<i>H</i>)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist

Mitsunori Kono, Atsuko Ochida, Tsuneo Oda et al. · Journal of Medicinal Chemistry · 2018 · 63 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Novel HDAC6 Inhibitors Increase Tubulin Acetylation and Rescue Axonal Transport of Mitochondria in a Model of Charcot–Marie–Tooth Type 2F

Róbert Adalbert, Akira Kaieda, Christina Antoniou et al. · ACS Chemical Neuroscience · 2019 · 35 citations

Life Sciences, Neuroscience, Pharmacology +14

Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist

Akira Shibata, Keiko Uga, Takayuki Sato et al. · Biochemical Pharmacology · 2018 · 31 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Synthesis and Biological Activities of 4-Phenyl-5-pyridyl-1,3-thiazole Derivatives as Selective Adenosine A3 Antagonists

Seiji Miwatashi, Yasuyoshi Arikawa, Tatsumi Matsumoto et al. · Chemical and Pharmaceutical Bulletin · 2008 · 28 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds

Junya Shirai, Yoshihide Tomata, Mitsunori Kono et al. · Bioorganic & Medicinal Chemistry · 2017 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17