Richard Luke

Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background

Barry R. Davies, Hannah E. Greenwood, Phillippa Dudley et al. · Molecular Cancer Therapeutics · 2012 · 453 citations

Pharmacotherapy, Cancer Biology, Tumor Biology +18

Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor

Richard A. Norman, Simon T. Barry, Michael Bate et al. · Structure · 2004 · 97 citations · Full text

Crystal Structure, Biochemistry, Natural Sciences +8

Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase.

Alexander L. Breeze, B. V. Kara, Derek Barratt et al. · The EMBO Journal · 1996 · 54 citations

Protein Function, Signal Transduction, Biochemistry +12

Synthesis of Cytidine Ribonucleotides by Stepwise Assembly of the Heterocycle on a Sugar Phosphate

Abdul‐Aziz Ingar, Richard Luke, Barry R. Hayter et al. · ChemBioChem · 2003 · 52 citations

Asymmetry in the boronic acid Mannich reaction: diastereocontrolled addition to chiral iminium species derived from aldehydes and (S)-5-phenylmorpholin-2-one

Laurence M. Harwood, Gordon S. Currie, Michael G. B. Drew et al. · Chemical Communications · 1996 · 48 citations

Methylated Derivative 4, Biochemistry, Chiral Iminium Species +10