Gordon S. Currie

Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

M. Raymond V. Finlay, Mark J. Anderton, Susan Ashton et al. · Journal of Medicinal Chemistry · 2014 · 590 citations · Full text

Genetics, Pathology, Clinical Candidate +18

Optimization of a Novel Binding Motif to (<i>E</i>)-3-(3,5-Difluoro-4-((1<i>R</i>,3<i>R</i>)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1<i>H</i>-pyrido[3,4-<i>b</i>]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist

Chris De Savi, Robert H. Bradbury, Alfred A. Rabow et al. · Journal of Medicinal Chemistry · 2015 · 159 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Positive Breast Cancer +18

Catalytic Enantioselective Intermolecular Hydroacylation: Rhodium-Catalyzed Combination of β-<i>S</i>-Aldehydes and 1,3-Disubstituted Allenes

James Osborne, Helen E. Randell‐Sly, Gordon S. Currie et al. · Journal of the American Chemical Society · 2008 · 153 citations

Cross-coupling Reaction, Me-duphos Ligand Promotes, Engineering +11

Chelation-Controlled Intermolecular Alkene and Alkyne Hydroacylation: The Utility of β-Thioacetal Aldehydes

Michael C. Willis, Helen E. Randell‐Sly, Robert L. Woodward et al. · Organic Letters · 2005 · 77 citations

Cross-coupling Reaction, Engineering, Alkene Metathesis +13

Rhodium-Catalyzed Intermolecular Chelation Controlled Alkene and Alkyne Hydroacylation:  Synthetic Scope of β-<i>S</i>-Substituted Aldehyde Substrates

Michael C. Willis, Helen E. Randell‐Sly, Robert L. Woodward et al. · The Journal of Organic Chemistry · 2006 · 75 citations