Bruce Carrington

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer

James P. O’Connell, John Porter, Boris Kroeplien et al. · Nature Communications · 2019 · 131 citations · Full text

Medicine, Immunology, Pharmacology +12

Prolonged in Vivo Residence Times of Antibody Fragments Associated with Albumin

Bryan John Smith, Andrew G. Popplewell, Dee Athwal et al. · Bioconjugate Chemistry · 2001 · 92 citations

Pharmacy, Biochemistry, Biotechnology +17

Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

David McMillan, C. Martinez-Fleites, John Porter et al. · Nature Communications · 2021 · 90 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +15

Discovery and characterization of olokizumab

Stevan Shaw, Tim Bourne, Chris Meier et al. · mAbs · 2014 · 86 citations · Full text

Life Sciences, Immunology, Pharmacology +17

A plasmid system for optimization of Fab′ production in Escherichia coli: importance of balance of heavy chain and light chain synthesis

David P. Humphreys, Bruce Carrington, Leigh C. Bowering et al. · Protein Expression and Purification · 2002 · 53 citations

Life Sciences, Biotechnology, Microbiology +16