Tim Bourne

Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti-tumor necrosis factor α agents

Andrew Nesbitt, Gianluca Fossati, Marianne Bergin et al. · Inflammatory Bowel Diseases · 2007 · 473 citations

Veterinary Medicine, Immunology, Pharmacology +17

Essential role for CD103 in the T cell–mediated regulation of experimental colitis

Oliver Annacker, Janine L. Coombes, Vivianne Malmström et al. · The Journal of Experimental Medicine · 2005 · 468 citations · Full text

Life Sciences, Cell Biology, Immunology +17

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

Ayaka Sugiura, Gabriela Andrejeva, Kelsey Voss et al. · Immunity · 2021 · 213 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer

James P. O’Connell, John Porter, Boris Kroeplien et al. · Nature Communications · 2019 · 131 citations · Full text

Medicine, Immunology, Pharmacology +12

CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study

Anthony Shock, Linda C. Burkly, Ian Wakefield et al. · Arthritis Research & Therapy · 2015 · 107 citations · Full text

Life Sciences, Hematology, Immunology +13