Jill Chrencik

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

Mark E. Schnute, Matthew D. McReynolds, Tom Kasten et al. · Biochemical Journal · 2012 · 274 citations

Specific Inhibitor, Whole Blood, Cellular Physiology +20

Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

Jill Chrencik, Akshay Patny, Iris Leung et al. · Journal of Molecular Biology · 2010 · 224 citations

Protein Function, Signal Transduction, Biochemistry +13

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

Jill Chrencik, C. Roth, Masahiko Terakado et al. · Cell · 2015 · 206 citations · Full text

Crystal Structure, Biochemistry, G Protein-coupled Receptor +4

Structural Disorder in the Complex of Human Pregnane X Receptor and the Macrolide Antibiotic Rifampicin

Jill Chrencik, Jillian Orans, Linda B. Moore et al. · Molecular Endocrinology · 2005 · 195 citations · Full text

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold et al. · Journal of Medicinal Chemistry · 2018 · 165 citations · Full text