Edmund I. Graziani

Novel Natural Products from Soil DNA Libraries in a Streptomycete Host

Gui-Yang-Sheng Wang, Edmund I. Graziani, Barbara Waters et al. · Organic Letters · 2000 · 259 citations

Bioorganic Chemistry, Engineering, Soil Dna Libraries +19

Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments

Frank Loganzo, Xingzhi Tan, Matthew Sung et al. · Molecular Cancer Therapeutics · 2015 · 254 citations

Breast Oncology, Immunology, Adc Resistance +16

Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy

L. Nathan Tumey, Manoj B. Charati, Tao He et al. · Bioconjugate Chemistry · 2014 · 184 citations

Medicinal Chemistry, Maleimide-based Adcs, Biochemistry +14

Mannopeptimycins, Novel Antibacterial Glycopeptides from <i>Streptomyces </i><i>h</i><i>ygroscopicus</i>, LL-AC98

Haiyin He, R. Thomas Williamson, Bo Shen et al. · Journal of the American Chemical Society · 2002 · 149 citations

Glycobiology, Novel Antibiotics, Antimicrobial Chemotherapy +16

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

Benfang Helen Ruan, Kevin Pong, Flora Jow et al. · Proceedings of the National Academy of Sciences · 2007 · 111 citations · Full text

Immunophilin Ligands, Cell Death, Synaptic Signaling +21