Saket Agarwal

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Kirk Brown, Jayaprakash K. Nair, Maja M. Janas et al. · Nature Biotechnology · 2022 · 225 citations · Full text

Rnai Therapeutics, Liver Physiology, Gene Delivery +5

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity

Liqing Wang, Suresh Kumar, Satinder Dahiya et al. · EBioMedicine · 2016 · 112 citations · Full text

Cancer Immunosurveillance, Cell Regulation, Promotes Antitumor Immunity +14

From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization

Mark K. Schlegel, Maja M. Janas, Yongfeng Jiang et al. · Nucleic Acids Research · 2022 · 84 citations · Full text

Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates

Maja M. Janas, Ivan Zlatev, Ju Liu et al. · Nucleic Acids Research · 2019 · 77 citations · Full text

Nucleic Acid Chemistry, Biochemistry, Natural Sciences +12

Towards in vitro models for reducing or replacing the use of animals in drug testing

David M. Stresser, Anna K. Kopec, Philip Hewitt et al. · Nature Biomedical Engineering · 2023 · 75 citations

Animal Testing, Xenotransplantation, Preclinical Drug Evaluation +11